OUR NEW PROFILE IS:   (NASDAQ: JAGX)

Mytesi®  is approved by the U.S. Food and Drug Administration for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy

Prescription product net revenue of $2.9 million in Q2 2022 increased approximately 12.0% Quarter over Quarter, over Q1 2022; and increased approximately 641% Year over Year, over Mytesi^® net revenue in Q2 2021

CHECK OUT THE CORPORATE PRESENTATION HERE

*****BREAKING NEWS JUST RELEASED MINUTES AGO*****

Jaguar Health Provides Company Updates and Reports 2022 Second Quarter Financials

Prescription product net revenue of $2.9 million in Q2 2022 increased approximately 12.0% Quarter over Quarter, over Q1 2022; and increased approximately 641% Year over Year, over Mytesi^® net revenue in Q2 2021

Core initiatives:

• OnTarget Phase 3 clinical trial of crofelemer for prophylaxis of cancer therapy-related diarrhea (CTD) adding international sites, targeting completion of enrollment 1H 2023
• Expected presentation in December 2022 of results of a third-party, investigator-initiated proof-of-concept trial of crofelemer for short bowel syndrome (SBS), supporting the potential for expanded patient access through programs in Europe in 2023
• Ongoing launch of Canalevia^®-CA1 for treatment of chemotherapy-induced diarrhea (CID) in dogs

REMINDER: Jaguar to host investor webcast Monday, August 22^nd at 8:30 a.m. Eastern regarding second quarter 2022 financials and company updates; Click here to register for webcast

SAN FRANCISCO, CA / ACCESSWIRE / August 22, 2022 / Jaguar Health, Inc. (NASDAQ:JAGX) (“Jaguar” or the “Company”) today provided Company updates and reported consolidated second-quarter 2022 financial results.

Prescription product net revenue was approximately $2.9 million in the second quarter of 2022, representing an increase of approximately 12% over Mytesi net revenue in the first quarter of 2022, which totaled approximately $2.6 million, and an increase of approximately 641% over Mytesi net revenue in the second quarter of 2021, which totaled approximately $0.4 million.

“We are very pleased that growth in Mytesi (crofelemer) revenue continued in the second quarter of 2022,” said Lisa Conte, Jaguar’s president and CEO. “We completed the full shift this past January to a patient access strategy that involves transitioning to a limited distribution network of specialty pharmacies, which reduced our distribution costs and improved our Mytesi gross-to-net ratio dramatically. It is wonderful to see Mytesi growth continuing following this transition and the other components of our Mytesi patient access program, including our ongoing educational and promotional activities in 2022 and the launch this past May of our telehealth initiative for Mytesi. Most importantly, we are pleased with the realization of our mission of providing relief with a novel, plant-based, first-in-class mechanism of action to patients in need – including patients for whom no alternative therapeutic options exist.”

“Jaguar is focused on two late-stage clinical events in the next approximately 6 to 12 months that we expect to be transformational in terms of value creation and recognition for the Company. We anticipate the completion in 2022 of an investigator-initiated proof-of-concept study of crofelemer for short bowel syndrome (SBS), supporting the potential for expanded patient access to crofelemer in Europe in 2023 for this devastating and often catastrophic disease for these patients, who are frequently on parenteral nutrition for as long as 20 hours a day, seven days a week. The third-party investigator, Dr. Mohamad Miqdady, Division Chief of the Pediatric Gastroenterology, Hepatology & Nutrition Division at Sheikh Khalifa Medical City, is targeting the presentation in December 2022 of results from the SBS study at a global GI conference in Dubai. Our second key clinical activity is our Phase 3 pivotal OnTarget trial of crofelemer for our core follow-on indication of prophylaxis of cancer therapy-related diarrhea (CTD). We expect enrollment in this pivotal trial to complete in the first half of 2023,” Conte said.

2022 MILESTONES, UPDATES & ACCOMPLISHMENTS:

• Phase 3 clinical trial of crofelemer for cancer therapy-related diarrhea (CTD) in humans: The pivotal OnTarget Phase 3 clinical trial of crofelemer for prophylaxis of CTD was initiated in October 2020and is ongoing. The Company is in the process of adding additional clinical trial sites – both in the US and outside the US – to accelerate patient enrollment. Further details about the trial can be viewed here on the clinicaltrials.gov website. Is it estimated that 50-80% of chemotherapy patients experience diarrhea,¹ and diarrhea has the potential to cause dehydration, potential infections, and non-adherence to treatment in cancer patients. Patients with CTD are 40% more likely to discontinue their chemotherapy or targeted therapy than patients without CTD,² and the cost of care of CTD patients is estimated to be 2.9 times higher than for patients who are not experiencing CTD.³
• 2022 & 2023 Milestones: Completion of investigator-initiated proof-of-concept studies of crofelemer for SBS and congenital diarrheal disorders (CDD) with intestinal failure: Napo Therapeutics, the Italy-based company Jaguar established under exclusive license to crofelemer in Europe, is supporting planned investigator-initiated studies of crofelemer in patients with SBS or CDD with intestinal failure, with a planned primary endpoint of reduction of weekly volume of parenteral nutrition. On December 13, 2021, the EMA granted Orphan Drug Designation (ODD) for crofelemer for SBS in the European Union, and crofelemer has received ODD in the U.S. for SBS. The EMA is committed to enabling early patient access to new medicines, particularly those that target an unmet medical need, and ODD status in the EU is expected to support Napo Therapeutics’ plans to make crofelemer available through Early Access Programs in the EU for SBS. Participation in Early Access Programs provides a potential opportunity for meaningful revenue generation in addition to the ability to impact important morbidity, mortality, and the cost of care for chronically ill patients for whom no good therapeutic options exist. SBS affects approximately 10,000 to 20,000 people in the U.S.,⁴ according to the Crohn’s & Colitis Foundation, and it is estimated that the population of SBS patients in Europe is approximately the same size.⁵ Despite limited treatment options, the global SBS market exceeded $568 million in 2019 and is expected to reach $4.6 billion by 2027, according to a report by Vision Research Reports.
• May 2022 submission of an Orphan Drug Designation (ODD) application to the European Medicines Agency (EMA) for crofelemer for a rare congenital diarrheal disorder (CDD): Napo Therapeutics, the Italian corporation established by the Company in Italy in 2021 that focuses on expanding crofelemer access in Europe, submitted a CDD ODD application for crofelemer to the EMA. CDDs are a group of inherited chronic enteropathies characterized by heterogeneous etiology, and each type of CDD is thus a different disease with a different pathogenetic mechanism. CDD is a life-threatening and rare autosomal recessive disease that affects newborns and children and leads to significant morbidity and even death from severe secretory diarrhea.
• Q3 2022 Milestone: Filing of an Investigational New Drug (IND) application with the FDA for NP-300 (lechlemer) for the symptomatic relief of diarrhea from cholera: Lechlemer is the Company’s drug product candidate for symptomatic relief of diarrhea from cholera. It is a standardized and proprietary botanical drug product that is sustainably derived from the same source as crofelemer – the Croton lechleri tree – and works by the same mechanism of action as crofelemer. In support of the planned IND application filing for lechlemer, the Company received comprehensive animal toxicity preclinical services supported by the National Institute of Allergy and Infectious Diseases for four preclinical studies. The Company intends to pursue a tropical disease priority review voucher under the FDA’s financial incentive program to develop drugs for tropical diseases such as cholera. Priority review vouchers are transferable, and in past transactions by other companies have sold for prices ranging from $67 million to $350 million, which provides for a potential immediate return on investment upon approval of the product for the symptomatic relief of diarrhea from cholera.
• 2022, Jaguar’s Year of the Dog: Launch activities remain underway for Canalevia-CA1 in the U.S. veterinary market for the treatment of chemotherapy-induced diarrhea (CID) in dogs, and the second quarter of 2022 is the first Canalevia-CA1 revenue recognition period for the Company. Canalevia-CA1 was the focus of Jaguar Animal Health’s activities at April’s Veterinary Cancer Society Mid-Year Conference in Puerto Vallarta, Mexico. Jaguar Animal Health exhibited at the June 23-25, 2022 American College of Veterinary Internal Medicine (ACVIM) Forum in Austin, Texas, and will be exhibiting at the September 7-11, 2022 International Veterinary Emergency and Critical Care Symposium (IVECCS) in San Antonio, Texas, and at the October 13-15, 2022 Veterinary Cancer Society (VCS) Annual Conference in Norfolk, Virginia. Dogs, as with humans, go off their disease modifying chemotherapy approximately 40% of the time due to diarrhea, and dogs are a predictive model of the human situation. Jaguar expects that Canalevia could additionally receive FDA conditional approval, under the name Canalevia^®-CA2, for the treatment of exercise-induced diarrhea (EID) in dogs in the next 6-8 months.
• Jaguar’s Canine Cancer: Take C.H.A.R.G.E. (Canine Health And ReGistry Exchange) initiative launched with a special media event and performance in New York City on May 23, 2022. Take C.H.A.R.G.E. established the first-ever U.S. canine cancer national registry and cancer care index to assess the prevalence and incidence of cancer in dogs. The mission is important, because protecting dogs from cancer begins with knowing its impact by breed, type, age, gender, and location. The data may also provide insights to help better understand cancer in humans and the importance of managing side effects in human cancer therapy. On August 10, 2022, Gallup published an article providing their analysis of results from Take Charge of Canine Cancer, the first-ever nationally representative survey of U.S. dog owners’ experiences with the disease. The survey, which comprises the Index component of the Take C.H.A.R.G.E. initiative, found that of the 67% of Americans who have had at least one dog in the past 10 years, nearly one in five – equating to approximately 30 million people – say at least one of their dogs has experienced cancer. Gallup’s article, which can be viewed by clicking here, also describes the Take C.H.A.R.G.E. initiative.

Ongoing business development initiatives in 2022:

• In June 2022, as announced, Jaguar entered an exclusive license and services agreement with Ontario, Canada-based SynWorld Technologies Corporation (SynWorld) for the treatment of diarrhea in dogs in the China market with Jaguar’s Canalevia drug product. Per the terms of the agreement, Jaguar has engaged SynWorld as a service provider to obtain regulatory approval of the product for Jaguar in China and granted SynWorld a license to commercialize and sell this product following such approval in China. As consideration for the license, Jaguar is entitled to receive 60% of any profits from sales of the product in China. If Jaguar reimburses SynWorld for the direct expense of obtaining regulatory approval in China, the profit sharing will be 80% and 20%, respectively, for Jaguar and SynWorld. The agreement also entails monthly license fee payments by SynWorld to Jaguar amounting to US $5.0 million in total during the initial two-year term of the agreement, realized as a commitment by SynWorld to make quarterly purchases of Jaguar common stock (purchased at market price in unregistered stock at the time of purchase). As consideration for the regulatory services to be provided by SynWorld, Jaguar will pay SynWorld a monthly service fee up to U.S. $5.0 million in total over the initial two-year term of the agreement in the form of unregistered Jaguar stock.
• In June 2022, as announced, Jaguar and Filament Health signed a letter of intent to enter a collaboration agreement to develop botanical prescription drugs for specific psychoactive target indications in the United States. The goal of the collaboration is to extend the botanical drug development skillsets of both companies in order to develop pharmaceutical-grade, standardized drug candidates and partner with a potential future licensee regarding the development and commercialization of these novel plant-based drugs for indications such as attention-deficit/hyperactivity disorder (ADHD) and social anxiety disorder. Jaguar’s Entheogen Therapeutics Initiative (ETI) aims to discover and develop groundbreaking, novel, natural medicines derived from psychedelic and psychoactive plants for treatment of mood disorders, neurodegenerative diseases, addiction, and mental health disorders. Jaguar is in discussions with potential partners for this initiative.
• The Company is continuing to manage its relationship with Quadri Pharmaceuticals Store LLC (Quadri Pharma) following the execution on March 31, 2022 of an exclusive crofelemer distribution and license agreement for multiple target indications in Middle East markets. As announced, the agreement grants Quadri Pharma exclusive promotional, commercialization, and distribution rights for specified human indications of crofelemer in Bahrain, Kuwait, Qatar, Saudi Arabia, the United Arab Emirates, and Oman following regulatory approval to market crofelemer in these countries for the specified indications, including the indication currently approved in the U.S. for HIV-related diarrhea, and cancer therapy-related diarrhea. In addition, the agreement grants Quadri Pharma exclusive rights to distribute crofelemer in these countries in the immediate future under Named Patient Programs. Jaguar expects patients in this territory to be able to access crofelemer before the end of 2022.
• Jaguar is continuing efforts to forge additional license and business development relationships in key markets around the globe.

Updates about recent and currently active investigator-initiated trials of crofelemer:

• Investigator-initiated HALT-D trial evaluating crofelemer for preventing chemotherapy-induced diarrhea (CID) in HER2-positive breast cancer patients: The full results of this study, which were presented at the San Antonio Breast Cancer Symposium (SABCS 2021) in December 2021, are being submitted to a medical journal in 2022 for consideration for publication.
• Chronic idiopathic diarrhea in non-HIV adult patients
  • Study Name: Yield of Diagnostic Tests and Management of Crofelemer for Chronic Idiopathic Diarrhea in Non-HIV Patients: A Pilot Study
  • Location: University of Texas Health Science Center at Houston
• Functional diarrhea in non-HIV adult patients
  • Study Name: A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and efficacy of crofelemer in subjects with functional diarrhea
  • Location: Beth Israel Deaconess Medical Center, a Harvard Medical School institution in Boston

2022 SECOND QUARTER COMPANY FINANCIAL RESULTS:

Prescription product net revenue was approximately $2.9 million in the second quarter of 2022, representing an increase of approximately 12% over Mytesi net revenue in the first quarter of 2022, which totaled approximately $2.6 million, and an increase of approximately 641% over Mytesi net revenue in the second quarter of 2021, which totaled approximately $0.4 million.

“Mytesi total prescription volume increased 8.2% in the second quarter of 2022 over the first quarter of 2022,” said Ian Wendt, Jaguar’s Chief Commercial Officer. “As previously announced, the transition we completed this past January to a limited distribution network of specialty pharmacies resulted in a meaningful reduction in Mytesi distribution costs as well as a higher average net price. I am very pleased to report that we significantly outperformed the industry gross-to-net average in the second quarter of 2022 – as we did in both of the two previous quarters – for sales of our human prescription product. This improvement in our gross-to-net was largely a result of the efficiencies realized by the transition to a closed network of specialty pharmacies. This transition assists in the preparation of the Company’s U.S. commercial distribution network for potential future indication expansion of crofelemer to other populations of patients with complex medical needs, such as CTD, inflammatory bowel disease, and SBS. Additionally, the transition has allowed us to begin utilizing sales and prescription data directly provided by our network of specialty pharmacies to more accurately track prescription metrics.”

The Company believes the availability of Mytesi through specialty pharmacies represents a significant benefit to patients, as such pharmacies focus on complex and chronic conditions and offer a higher level of support for prior authorizations, appeals, adherence reminders and counseling, and home delivery options.

• Mytesi Prescription Volume: As stated above, Mytesi prescription volume increased 8.2% in the second quarter of 2022 over the first quarter of 2022. Prescription volume differs from invoiced sales volume, which reflects, among other factors, varying buying patterns among specialty pharmacies in the closed network as they manage their inventory levels.
• Mytesi Net Product Revenue: Mytesi net revenue during the second quarter of 2022 was approximately $2.8 million and approximately $2.6 million in the first quarter of 2022, an increase of approximately $0.2 million, or approximately 10%, quarter over quarter, and an increase of approximately 644% over Mytesi net revenue in the second quarter of 2021, which totaled approximately $0.4 million. The transition to a limited distribution network of specialty pharmacies, which was completed this past January, resulted in a meaningful reduction in Mytesi distribution costs and a higher average net price. As part of the process of transitioning to the closed specialty pharmacy network, the third and fourth quarters of 2021 were significantly impacted by the inventory draw-down of approximately 1,300 bottles of Mytesi across the Company’s third-party logistics warehouse, wholesalers, distributors, and retail stores.
• Mytesi Gross Product Revenue (Non-GAAP): Mytesi gross revenue was approximately $3.7 million in the second quarter of 2022 and $3.4 million in the first quarter of 2022, representing an increase of approximately $0.3 million or 9% quarter over quarter, and a decrease of approximately 24% over Mytesi gross revenue in the second quarter of 2021, which totaled approximately $4.9 million.
• Canalevia-CA1 Net Product Revenue: Canalevia-CA1 (crofelemer delayed-release tablets), the Company’s prescription drug product for the treatment of chemotherapy-induced diarrhea (CID) in dogs, became commercially available to veterinarians across the U.S. at the end of April 2022. Canalevia-CA1 net and gross revenue during the second quarter of 2022 were approximately $87.4 thousand.
• Neonorm^™: Revenues for the non-prescription Neonorm products and Jaguar’s Animal Health business unit were minimal for the second quarters of 2022 and 2021, in accordance with the Company’s primary focus on human health and prescription products.

• Cost of Product Revenue: Total cost of product revenue for the quarter ended June 30, 2022 was $0.5 million compared to $0.7 million for the quarter ended June 30, 2021. The decrease of $0.2 million was largely due to lower distribution and channel rebate/discount costs that resulted from the shift to the specialty pharmacies distribution model.
• Research and Development: The R&D expense was $2.5 million for the second quarter of 2022 compared to $3.9 million for the second quarter of 2021, a decrease of $1.4 million. Clinical, contract manufacturing, personnel and related benefits decreased approximately $1.0 million in the second quarter of 2022 compared to the same period in 2021. During the second quarter of 2022 certain personnel and related benefits were capitalized as internally developed software costs for the Canine Cancer: Take C.H.A.R.G.E.Registry. Consulting, formulation and regulatory fees decreased $0.7 million from $0.9 million in the three months ended June 30, 2021 to $0.2 million in the same period in 2022. The decrease was due to lower clinical trial consulting costs.
• Sales and Marketing: The Sales and Marketing expense was $2.1 million for the second quarter of 2022 compared to $2.2 million for the second quarter of 2021, a decrease of $0.1 million.
• General and Administrative: The G&A expense was $4.3 million for the second quarter of 2022 compared to $5.1 million for the second quarter of 2021. The decrease of $0.8 million was largely due to a reduction of $0.1 million in personnel and related benefits, $0.5 million in public company expense and $0.1 in consulting costs. This is offset by increases of $0.03 million in travel expenses due to loosening of Covid-related travel restrictions, $0.1 million in rent and $0.7 million in Company financing activities.
• Loss from Operations: For the second quarter of 2022, the loss from operations was $6.5 million compared to a loss of $11.6 million in the second quarter of 2021, a decrease of $5.1 million.
• Net Loss: For the second quarter of 2022, the net loss attributable to common shareholders was approximately $9.4 million, compared to a net loss of $14.1 million in the second quarter of 2021, a decrease of approximately $4.7 million quarter over quarter. In addition to the loss from operations:
• Interest expense increased by $0.5 million from $2.0 million in the three months ended June 30, 2021 to $2.5 million for the same period in 2022 primarily due to interest from the royalty and note agreements.
• Change in fair value of financial instruments and hybrid instruments designated at fair value option (FVO) losses increased $1.2 million from a loss of $0.5 million in the three months ended June 30, 2021 to a gain of $0.7 million for the same period in 2022.
• Other expense increased by $1.1 million from $0.02 in the three months ended June 30, 2021 to $1.1 million for the same period in 2022 due to the foreign currency transactions.
• Non-GAAP EBITDA: Non-GAAP EBITDA for the second quarter of 2022 and the second quarter of 2021 was a net loss of $5.4 million and $10.8 million, respectively.

Note Regarding Use of Non-GAAP Measures

The Company supplements its condensed consolidated financial statements presented on a GAAP basis by providing gross sales, non-GAAP EBITDA, and non-GAAP recurring EBITDA, which are considered non-GAAP under applicable SEC rules. Jaguar believes that the disclosure items of these non-GAAP measures provide investors with additional information that reflects the basis upon which Company management assesses and operates the business. These non-GAAP financial measures are not in accordance with GAAP and should not be viewed in isolation or as substitutes for GAAP net sales and GAAP net loss and are not substitutes for, or superior to, measures of financial performance in conformity with GAAP.

Gross sales percentages issued by the Company are based on gross sales figures that represent Mytesi orders placed by select Specialty Pharmacies with Jaguar’s third-party logistics warehouse, less allowances for rebates and discounts, which generate the cash flows for Napo Pharmaceuticals, Inc. (“Napo”), Jaguar’s wholly owned subsidiary. Gross sales are used internally by management as an indicator of and to monitor operating performance, including sales performance of Mytesi, salesperson performance, and product growth or declines. Gross sales are not a measure that is recognized under accounting principles generally accepted in the United States of America (“GAAP”) and should not be considered as an alternative to net sales, which is determined in accordance with GAAP, and should not be used alone as an indicator of operating performance in place of net sales. Additionally, gross sales may not be comparable to similarly titled measures used by other companies, as gross sales have been defined by the Company’s internal reporting practices. In addition, gross sales may not be realized in the form of cash receipts as promotional payments and allowances may be deducted from payments received from certain customers. Mytesi gross sales are reduced by specialty pharmacy discounts, Medicare rebates, Medicaid rebates, 340B discounts, ADAP rebates, VA rebates, copay program costs, prompt pay discounts, and returns based on historical trends to determine net sales.

The Company defines non-GAAP EBITDA as net loss before interest expense and other expense, depreciation of property and equipment, amortization of intangible assets, share-based compensation expense and provision for or benefit from income taxes. The Company defines non-GAAP Recurring EBITDA as non-GAAP EBITDA adjusted for certain non-recurring revenues and expenses. Company management believes that non-GAAP EBITDA and non-GAAP Recurring EBITDA are meaningful indicators of Jaguar’s performance and provide useful information to investors regarding the Company’s results of operations and financial condition.

Participation Instructions for Webcast
When: Monday, August 22, 2022, at 8:30 AM Eastern Time
Participant Registration & Access Link: Click Here

Replay Instructions for Webcast
Replay of the webcast on the investor relations section of Jaguar’s website: (click here)

About Jaguar Health, Jaguar Animal Health, Napo Pharmaceuticals, & Napo Therapeutics

Jaguar Health, Inc. is a commercial stage pharmaceuticals company focused on developing novel, plant-based, non-opioid, and sustainably derived prescription medicines for people and animals with GI distress, including chronic, debilitating diarrhea. Jaguar Animal Health is a tradename of Jaguar Health. Jaguar Health’s wholly owned subsidiary, Napo Pharmaceuticals, Inc., focuses on developing and commercializing proprietary plant-based human pharmaceuticals from plants harvested responsibly from rainforest areas. Our crofelemer drug product candidate is the subject of the OnTarget study, an ongoing pivotal Phase 3 clinical trial for prophylaxis of diarrhea in adult cancer patients receiving targeted therapy. Jaguar Health is the majority shareholder of Napo Therapeutics S.p.A. (f/k/a Napo EU S.p.A.), an Italian corporation established by Jaguar Health in Milan, Italy in 2021 that focuses on expanding crofelemer access in Europe.

For more information about Jaguar Health, please visit https://jaguar.health. For more information about Napo Pharmaceuticals, visit www.napopharma.com.

About Mytesi^®

Mytesi (crofelemer) is an antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). Mytesi is not indicated for the treatment of infectious diarrhea. Rule out infectious etiologies of diarrhea before starting Mytesi. If infectious etiologies are not considered, there is a risk that patients with infectious etiologies will not receive the appropriate therapy and their disease may worsen. In clinical studies, the most common adverse reactions occurring at a rate greater than placebo were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and increased bilirubin (3.1%).

See full Prescribing Information at Mytesi.com. Crofelemer, the active ingredient in Mytesi, is a botanical (plant-based) drug extracted and purified from the red bark sap of the medicinal Croton lechleri tree in the Amazon rainforest. Napo has established a sustainable harvesting program for crofelemer to ensure a high degree of quality and ecological integrity.

Important Safety Information About Canalevia^®-CA1

For oral use in dogs only. Not for use in humans. Keep Canalevia-CA1 (crofelemer delayed-release tablets) in a secure location out of reach of children and other animals. Consult a physician in case of accidental ingestion by humans. Do not use in dogs that have a known hypersensitivity to crofelemer. Prior to using Canalevia-CA1, rule out infectious etiologies of diarrhea. Canalevia-CA1 is a conditionally approved drug indicated for the treatment of chemotherapy-induced diarrhea in dogs. The most common adverse reactions included decreased appetite, decreased activity, dehydration, abdominal pain, and vomiting.

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Use only as directed. It is a violation of Federal law to use this product other than as directed in the labeling. Conditionally approved by FDA pending a full demonstration of effectiveness under application number 141-552.

See full Prescribing Information at Canalevia.com.

___________________

Hello Everyone,

We have a company back on our radar for Monday’s session that we recently took a look at just under two weeks ago.

We profiled it before the open and it saw gap up about a penny and a half gap and opened at .285.  It moved up over the next few sessions hitting a high of .32 for a nice 12% move in just a few sessions.  Over the past few sessions it has seen a little bit of a pullback and is sitting around .27 right now.

We have a major catalyst to look at today:

 

Jaguar Health to Host Investor Webcast Monday, August 22nd at 8:30 AM Eastern Time Regarding Q2 2022 Financials & Corporate Updates https://t.co/dks4EjuVFM pic.twitter.com/uUuH3smi1z

— Jaguar Health (@Jaguar_Health) August 17, 2022

 

There will be a lot of eyes on these earnings today with this one trading for such a low price right now.

There is also another catalyst to look at:

Jaguar Health Receives Additional 180-day Grace Period to Regain Compliance with Nasdaq’s Bid Price Rule https://t.co/DtSZepNljk pic.twitter.com/dqULkZrVdG

— Jaguar Health (@Jaguar_Health) August 19, 2022

Long story short, the company has a lot of motivation to do everything they can to move the price of this one up over the next 6 months.  If the company has any positive news to be released, you can assume it will be coming out in the next few months.

Make sure JAGX is on your screen right now.  

Jaguar Health, Inc. is a commercial stage pharmaceuticals company focused on developing novel, plant-based, non-opioid, and sustainably derived prescription medicines for people and animals with GI distress, specifically chronic, debilitating diarrhea. Jaguar Animal Health is a tradename of Jaguar Health. Jaguar Health’s wholly owned subsidiary, Napo Pharmaceuticals, Inc., focuses on developing and commercializing proprietary plant-based human gastrointestinal pharmaceuticals from plants harvested responsibly from rainforest areas. Napo Pharmaceuticals’ Mytesi® (crofelemer) product is approved by the U.S. Food and Drug Administration for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy and is the only oral plant-based prescription medicine approved under FDA Botanical Guidance. Crofelemer is the subject of the OnTarget study, an ongoing pivotal Phase 3 clinical trial for prophylaxis of diarrhea in adult cancer patients receiving targeted therapy.
Jaguar Health is the majority shareholder of Napo Therapeutics S.p.A., an Italian corporation established by Jaguar Health in Milan, Italy in 2021 that focuses on a rare disease business model, including an initial focus on the orphan designation of crofelemer for short bowel syndrome for which proof of concept data is expected in the next 6 months. Napo Therapeutics is pursuing the rare disease strategy to bring crofelemer to patients in need, potentially in 2023, under the reimbursed expanded patient access program that exists in EU.

PRODUCTS AND PIPELINE

Mytesi

Mytesi^® (crofelemer), a product of Jaguar’s wholly-owned subsidiary Napo Pharmaceuticals, is approved by the FDA for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy.

Mytesi is a novel, first‑in‑class anti‑secretory agent which has a basic normalizing effect locally on the gut, and this mechanism of action has the potential to benefit multiple gastrointestinal disorders. Jaguar, through Napo, holds extensive global rights for Mytesi. Mytesi is in development for multiple possible follow‑on indications, including diarrhea related to targeted cancer therapy; orphan‑drug indications for infants and children with congenital diarrheal disorders and short bowel syndrome; supportive care for inflammatory bowel disease; irritable bowel syndrome; and for idiopathic/functional diarrhea. In addition, a second‑generation proprietary anti‑secretory agent is in development for cholera.

Crofelemer, the active ingredient in Mytesi^®, is a botanical (plant-based) drug extracted and purified from the red bark sap of the medicinal Croton lechleri tree in the Amazon rainforest. Napo has established a sustainable harvesting program for crofelemer to ensure a high degree of quality and ecological integrity.

 

The term ethnobotanical refers to the use of plants by indigenous people in the course of their everyday lives, including the use of plants for medicine. Crofelemer, the active pharmaceutical ingredient in Mytesi, is derived from the Amazonian tree species, Croton lechleri, and has a rich history of medicinal use by indigenous peoples in the Western Amazon rainforests of South America. The tree produces a blood red latex from which crofelemer is isolated and purified. The tree is commonly called “Sangre de drago” in Spanish, which translates to “Dragon’s blood” in English.

The Croton lechleri tree is one of the most widely used plant-derived medicines in the western hemisphere. Red latex from Croton lechleri trees continues to be part of rural and urban traditional medicine in multiple countries including Peru, Colombia, Ecuador, and Bolivia.

Indigenous people utilize the red latex to treat a variety of medical conditions. Its most common uses are taking small quantities of the latex orally to treat diarrhea, stomach ulcers, coughs, and flu. The red latex is also applied topically as a wound healing agent for cuts and open sores, and for healing the gums after tooth extractions. It has been and continues to be used to treat humans as well as dogs and livestock.

Because of its widespread medicinal use, there has been extensive research conducted on the chemistry and pharmacology of this red latex. Mytesi is the result of decades of research that began with the expertise of traditional healers of the Amazon Rainforest.

The Croton lechleri tree is rapidly growing and abundant in multiple countries. Jaguar and its predecessor companies always focus on the long-term sustainable management of the tree as part of our commitment to helping local communities both conserve their natural resources while also earning income for the basic needs of their families, such as food, clothing, health care and education. Jaguar employees have been collaborating with local communities, business partners and scientists for the past 30 years to make certain that the development and sale of this product provides benefit to local communities. Large numbers of these trees have been planted, and re-planted upon harvesting, across Peru in collaboration with communities and small local businesses.

JAGUAR ANIMAL HEALTH

Jaguar Animal Health is an animal health company focused on creating plant-based gastrointestinal products for companion and production animals, foals, and high-value horses. Jaguar Animal Health is committed to discovering, developing, and commercializing plant-based prescription medicines and non-prescription products for animal health needs on a global basis. Each of our products are first-in-class and sustainably derived to ensure the highest degree of quality and ecological integrity.

Jaguar Animal Health continues to support the discovery and development of medicines from its proprietary library of 2,300 plants; presenting its four-legged patients with an increasing number of options for effective bio-based treatments.​

Canalevia-CA1 is the lead prescription drug product for Jaguar Animal Health and is intended for the treatment of chemotherapy-induced diarrhea (CID) in dogs.

Entheogen Therapeutics Initiative

In September 2020, Jaguar launched the Entheogen Therapeutics Initiative (ETI) to support the discovery and development of novel, plant-based medicines derived from psychoactive plants for treatment of mood disorders, neuro-degenerative diseases, addiction, and other mental health disorders.

ETI is initially focused on plants from the company’s proprietary library of 2,300 plants, with the objective of identifying plants that may have the potential to treat mood disorders, including depression, which affects more than 264 million people of all ages around the globe, according to the World Health Organization. Though the market for antidepressants is expected to reach $19 billion by 2023 and is dominated by selective serotonin reuptake inhibitor (SSRI) drugs, an estimated 30 percent of patients are not effectively treated with SSRIs.

The Growing Market for Medicines Derived from Psychoactive Plants

According to the World Health Organization, one in four people in the world will be affected by mental or neurological disorders at some point in their lives. Around 450 million people currently suffer from such conditions, placing mental disorders among the leading causes of ill-health and disability worldwide. Common mental health conditions include depression, PTSD, anxiety, addiction, bipolar disorder (formerly called manic-depressive illness or manic depression), and anorexia nervosa, and expand to include neuro-degenerative diseases such as Parkinson’s, Alzheimer’s disease, and ALS (amyotrophic lateral sclerosis), among others. Substance use disorders occur when the recurring use of alcohol and/or drugs causes clinically significant impairment, including health problems, disability, and failure to meet major responsibilities at work, home, or school. The Lancet Commission, a group of experts in neuroscience, psychiatry, public health, and related fields, estimates that the cost of mental disorders, currently on the rise in every country, will reach $16 trillion by 2030, including costs associated with lost productivity.

Picralima nitida plant, a species of West African plant of the genus Picralima in the family Apocynaceae, and the source of the active ingredient alstonine

Clinical research by third parties using psychoactive plants is beginning to show positive results. Psilocybin, the psychoactive ingredient found in more than 200 species of mushrooms, received Breakthrough Therapy designation from the U.S. Food and Drug Administration (FDA) in 2018 for treatment resistant depression and in 2019 for major depressive disorder, and MDMA (midomafetamine) received Breakthrough Therapy designation from FDA for posttraumatic stress disorder in 2017. MC-18, a chemical modification of the active chemical component in certain hallucinogenic plants and the recently approved chemical component in Johnson & Johnson subsidiary Janssen Pharmaceuticals’ nasal spray Spravato® (esketamine), is a synthetic analog to the “club drug” ketamine. Spravato received Fast Track and Breakthrough Therapy designations from FDA and is the first novel non-SSRI antidepressant approved by the FDA in more than 20 years.

Plant-derived psychoactive compounds appear to have a novel mechanism of action that targets higher regions of the brain than the most widely used SSRI class. These higher regions of the brain are believed to be where the pathology/biology of depression lies.

There appears to be growing enthusiasm among patients and the healthcare community for pure compounds derived from psychoactive plants, likely because of encouraging clinical trial results, and a survey of 2,000 Americans conducted by OnePoll found one in two of those surveyed have eschewed more traditional medicine in favor of natural alternatives.

Leveraging Jaguar’s Library of 2,300 Medicinal Plants

Jaguar’s library of approximately 2,300 medicinal plants from tropical regions comprises a unique asset to drive drug discovery. The plant collection was assembled over a decade by integrated ethnobotanist physician teams who conducted primary, first-hand field investigations and plant identification work in rainforest regions around the globe in addition to gathering data about traditional medicinal uses of plants from shamans and other Indigenous healers. Jaguar also has FDA-approved commercial GMP manufacturing systems in place, which has allowed the company to take crofelemer from a plant sustainably harvested in the rainforest to a pure compound and finished, FDA-approved prescription product: Mytesi.

Banisteriopsis Caapi flowers, one of the Ayahuasca plants

Jaguar’s team has always recognized and valued the unique and powerful knowledge Indigenous and traditional peoples have about plants, ecosystems, and healing compounds, and the company looks forward to continuing its mission to advance sustainably derived plant-based medicines while establishing a responsible harvesting program to ensure both quality and ecological integrity.

Jaguar’s library contains plant specimens gathered from Central America, South America, Africa, and South East Asia, including a broad diversity of plant extracts from roots, shrubs, bark, leaves, fruits and seeds.

Jaguar Health Provides Company Updates and Reports 2022 First Quarter Financials

Mytesi^® net revenue of $2.6 million increased approximately 24% over the fourth quarter of 2021 and increased approximately 112% over Mytesi net revenue in the first quarter of 2021

Core initiatives:

• OnTarget Phase 3 clinical trial of crofelemer for prophylaxis of cancer therapy-related diarrhea (CTD) adding international sites, targeting completion of enrollment 1H 2023
• Targeted completion in 2022 & 2023 of investigator-initiated proof-of-concept studies of crofelemer for short bowel syndrome and congenital diarrheal disorders, supporting the potential for expanded patient access through programs in Europe in 2023
• Ongoing launch of Canalevia^®-CA1, which is now commercially available for treatment of chemotherapy-induced diarrhea (CID) in dogs

SAN FRANCISCO, CA / ACCESSWIRE / May 10, 2022 / Jaguar Health, Inc. (NASDAQ:JAGX) (“Jaguar” or the “Company”) today provided company updates and reported consolidated first quarter 2022 financial results.

Mytesi net revenue was approximately $2.6 million in the first quarter of 2022, representing an increase of approximately 24% over Mytesi net revenue in the fourth quarter of 2021, which totaled approximately $2.1 million, and an increase of approximately 112% over Mytesi net revenue in the first quarter of 2021, which totaled approximately $1.2 million.

“These increases in Mytesi revenue largely represent the important and continuing realization of the benefits – from both a financial perspective and the standpoint of improved patient access – from the shift Jaguar completed this past January to distributing Mytesi through a closed network of specialty pharmacies (rather than to wholesalers that resell the product to retail pharmacies). I am also pleased to announce that Canalevia-CA1 (crofelemer), our prescription product for chemotherapy-induced diarrhea (CID) in dogs, is now commercially available,” said Lisa Conte, Jaguar’s president and CEO. “Regarding future commercial opportunities, Jaguar is focused on two important crofelemer pipeline development activities in the next 12-15 months that are expected to be value-creating: the completion of enrollment for our Phase 3 pivotal OnTarget trial of our core follow-on indication for crofelemer’s novel mechanism of action, prophylaxis of cancer therapy-related diarrhea (CTD) in humans; and the completion in 2022 and 2023 of investigator-initiated proof-of-concept studies of crofelemer for short bowel syndrome (SBS) and congenital diarrheal disorders (CDD), supporting the potential for expanded patient access through programs in Europe in 2023 for these devastating and catastrophic diseases and health situations for these patients, who are often on parenteral nutrition for as long as 20 hours a day, seven days a week.”

2022 MILESTONES, UPDATES & ACCOMPLISHMENTS:

“We look forward to 2022 continuing to be an exciting year, with continued development initiatives for crofelemer – our ‘pipeline within a product’; continuing efforts to forge license and business development relationships, such as the recently completed license and distribution deal with Quadri Pharma for the MENA region; our ongoing Canalevia-CA1 launch, and potential expansion of Canalevia conditional approval to exercise-induced diarrhea (EID) in dogs; and continued growth in sales of Mytesi, with the successful completion of the shift to our specialty pharmacies distribution and continued educational and promotional activities in 2022, including the recent launch of our telehealth initiative. Most importantly, we are pleased with the realization of our mission of providing relief with a novel, plant-based, first-in-class mechanism of action to patients in need – including patients for whom no alternative therapeutic options exist,” Conte said.

• Phase 3 clinical trial of crofelemer for cancer therapy-related diarrhea (CTD) in humans: The pivotal OnTarget Phase 3 clinical trial of crofelemer for prophylaxis of CTD was initiated in October 2020 and is ongoing. The Company is in the process of adding additional clinical trial sites – both in the US and outside the US – to accelerate patient enrollment. Further details about the trial can be viewed here on the clinicaltrials.gov website. A significant proportion of patients undergoing cancer therapy experience diarrhea, and diarrhea has the potential to cause dehydration, potential infections, and non-adherence to treatment in this patient population. Patients with CTD are 40% more likely to discontinue their chemotherapy or targeted therapy than patients without CTD,¹ and the cost of care of CTD patients is estimated to be 2.9 times higher than for patients who are not experiencing CTD.²
• 2022 & 2023 Milestones: Completion of investigator-initiated proof-of-concept studies of crofelemer for short bowel syndrome (SBS) and congenital diarrheal disorders (CDD) with intestinal failure: Napo Therapeutics is supporting planned investigator-initiated studies of crofelemer in patients with short bowel syndrome (SBS) or congenital diarrheal disorders (CDD) with intestinal failure, with a planned primary endpoint of reduction of weekly volume of parenteral nutrition. On December 13, 2021, the European Medicines Agency (EMA) granted orphan-drug designation (ODD) for crofelemer for SBS in the European Union, and crofelemer has received ODD in the U.S. for SBS. The EMA is committed to enabling early patient access to new medicines, particularly those that target an unmet medical need, and ODD status in the EU is expected to support Napo Therapeutics’ plans to make crofelemer available through Early Access Programs in the EU for SBS. Participation in Early Access Programs provides a potential opportunity for meaningful revenue generation in addition to the ability to impact important morbidity, mortality, and the cost of care for chronically ill patients for whom no good therapeutic options exist. SBS affects approximately 10,000 to 20,000 people in the U.S.,³according to the Crohn’s & Colitis Foundation, and it is estimated that the population of SBS patients in Europe is approximately the same size.⁴ Despite limited treatment options, the global SBS market exceeded $568 million in 2019 and is expected to reach $4.6 billion by 2027, according to a report by Vision Research Reports.
• Mid-2022 Milestone: Filing of an Investigational New Drug (IND) application with the FDA for NP-300 (lechlemer) in support of the initiation of a Phase 1 lechlemer study in 2H 2022 for the symptomatic relief of diarrhea from cholera: Lechlemer is the company’s drug product candidate for symptomatic relief of diarrhea from cholera. It is a standardized and proprietary botanical drug product that is sustainably derived from the same source as crofelemer – the Croton lechleri tree, and works by the same mechanism of action as crofelemer. In support of the planned IND application filing for lechlemer, the Company received comprehensive animal toxicity preclinical services supported by the National Institute of Allergy and Infectious Diseases for four preclinical studies. The Company intends to pursue a tropical disease priority review voucher under the FDA’s financial incentive program to develop drugs for tropical diseases such as cholera. Priority review vouchers are transferable, and in past transactions by other companies have sold for prices ranging from $67 million to $350 million, which provides for a potential immediate return on investment upon approval of the product for the symptomatic relief of diarrhea from cholera.
• 2022: Jaguar’s Year of the Dog: Launch activities remain underway for Canalevia-CA1 in the U.S. veterinary market for the treatment of chemotherapy-induced diarrhea (CID) in dogs. Canalevia-CA1 was the focus of Jaguar Animal Health’s exhibit booth at April’s Veterinary Cancer Society Mid-Year Conference in Puerto Vallarta, Mexico, and the Company also held a well-attended dinner event for veterinary oncologists about CID in dogs at this conference. Jaguar Animal Health will be exhibiting at the June 23-25, 2022 American College of Veterinary Internal Medicine (ACVIM) Forum in Austin, Texas. Dogs, as with humans, go off their disease modifying chemotherapy approximately 40% of the time due to diarrhea, and dogs are a predictive model of the human situation. As announced, Jaguar expects that Canalevia could additionally receive FDA conditional approval, under the name Canalevia^®-CA2, for the treatment of exercise-induced diarrhea (EID) in dogs in the fourth quarter of 2022.

READ THE ENTIRE PRESS RELEASE HERE

Jaguar Health Announces Napo Therapeutics’ Submission of Orphan Drug Designation Application to the European Medicines Agency for Crofelemer for a Severe Congenital Diarrheal Disorder (CDD) Condition https://t.co/ufIrkAIDua pic.twitter.com/w1GztVQPYy

— Jaguar Health (@Jaguar_Health) May 25, 2022

Sincerely,

The Viral Stocks Team

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